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Phenotypes Associated with This Genotype
Genotype
MGI:4367276
Allelic
Composition
Mmp2tm1Ito/Mmp2tm1Ito
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp2tm1Ito mutation (1 available); any Mmp2 mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mice exhibit 35% less ischemia-induced retinal neovascularization compared with similarly treated wild-type mice (J:113620)
• mice exhibit 35% less ischemia-induced retinal neovascularization compared with similarly treated wild-type mice (J:113620)

skeleton
• hyperteloric with narrower, taller skulls (J:121780)
• overall skull lengths are decreased and about 10% shorter by 12 weeks of age (J:121780)
• area between the right and left frontal-squamosal intersection at the temporal crest, mid-cranial width, is wider and this difference increases with age (J:121780)
• mid-cranial width differences continue to increase from about 10% at 4 weeks to nearly 25% at 24 weeks (J:121780)
• hyperteloric with narrower, taller skulls (J:121780)
• overall skull lengths are decreased and about 10% shorter by 12 weeks of age (J:121780)
• area between the right and left frontal-squamosal intersection at the temporal crest, mid-cranial width, is wider and this difference increases with age (J:121780)
• mid-cranial width differences continue to increase from about 10% at 4 weeks to nearly 25% at 24 weeks (J:121780)
• coronal sutures are prominent and sclerotic (J:121780)
• coronal sutures are prominent and sclerotic (J:121780)
• lambdoid sutures are prominent and sclerotic (J:121780)
• lambdoid sutures are prominent and sclerotic (J:121780)
• sagittal sutures are prominent and sclerotic (J:121780)
• sagittal sutures are prominent and sclerotic (J:121780)
• lower jaw length is about 10% shorter by 12 weeks of age (J:121780)
• lower jaw length is about 10% shorter by 12 weeks of age (J:121780)
• upper jaw length is about 10% shorter by 12 weeks of age (J:121780)
• upper jaw length is about 10% shorter by 12 weeks of age (J:121780)
• bone marrow has transiently decreased osteoclast numbers (J:121780)
• osteoblast and osteoclast numbers per trabecular bone surface area are decreased by more than half at 4 days of age, but no differences are seen at 4 and 12 weeks of age, indicating a transient decrease (J:121780)
• bone marrow has transiently decreased osteoclast numbers (J:121780)
• osteoblast and osteoclast numbers per trabecular bone surface area are decreased by more than half at 4 days of age, but no differences are seen at 4 and 12 weeks of age, indicating a transient decrease (J:121780)
• femoral condyles and proximal tibiae show cartilage destruction with erosions of cartilage occupied by fibrous tissue and inflammatory cells (J:121780)
• femoral condyles and proximal tibiae show cartilage destruction with erosions of cartilage occupied by fibrous tissue and inflammatory cells (J:121780)
• 6 month old mutants show a slight shortening of long bones (J:121780)
• 6 month old mutants show a slight shortening of long bones (J:121780)
• progressive loss of bone mineral density; mutants begin to show loss at 5 weeks of age and show a 20% reduction at 10 weeks of age that persists throughout early adulthood, and with more rapid loss after 20 weeks of age (J:121780)
• progressive loss of bone mineral density; mutants begin to show loss at 5 weeks of age and show a 20% reduction at 10 weeks of age that persists throughout early adulthood, and with more rapid loss after 20 weeks of age (J:121780)
• 13.4% decrease in bone volume at 24 weeks of age (J:121780)
• 13.4% decrease in bone volume at 24 weeks of age (J:121780)
• defects in cortical bone formation in 4 day old mutants that appear to mostly resolve by 4 weeks of age (J:121780)
• cortical bone continues to show large areas of woven bone compared to normal lamellar tissue in wild-type bone at 4 and 12 weeks of age (J:121780)
• defects in cortical bone formation in 4 day old mutants that appear to mostly resolve by 4 weeks of age (J:121780)
• cortical bone continues to show large areas of woven bone compared to normal lamellar tissue in wild-type bone at 4 and 12 weeks of age (J:121780)
• bone marrow has transiently decreased osteoblast numbers (J:121780)
• osteoblast and osteoclast numbers per trabecular bone surface area are decreased by more than half at 4 days of age, but no differences are seen at 4 and 12 weeks of age, indicating a transient decrease (J:121780)
• bone marrow has transiently decreased osteoblast numbers (J:121780)
• osteoblast and osteoclast numbers per trabecular bone surface area are decreased by more than half at 4 days of age, but no differences are seen at 4 and 12 weeks of age, indicating a transient decrease (J:121780)
• defects in trabecular bone formation in 4 day old mutants that appear to mostly resolve by 4 weeks of age (J:121780)
• primary spongiosa and trabeculae appear less dense and more scant (J:121780)
• defects in trabecular bone formation in 4 day old mutants that appear to mostly resolve by 4 weeks of age (J:121780)
• primary spongiosa and trabeculae appear less dense and more scant (J:121780)
• knee joints of all 12 week old mutants show articular cartilage destruction and erosion of the underlying bone surface resulting in the loss of the smooth tibial and femoral surfaces (J:121780)
• knee joints of all 12 week old mutants show articular cartilage destruction and erosion of the underlying bone surface resulting in the loss of the smooth tibial and femoral surfaces (J:121780)
• bone of 4 day old mutants shows overall paucity and chaotic organization of trabecular bone, and marked hypocellularity and ragged metaphyseal and diaphyseal cortical bone, a phenotype seen in earlier embryological time points, indicating retarded bone growth (J:121780)
• stigmata of abnormal cortical growth remains at 4 weeks of age (J:121780)
• bone of 4 day old mutants shows overall paucity and chaotic organization of trabecular bone, and marked hypocellularity and ragged metaphyseal and diaphyseal cortical bone, a phenotype seen in earlier embryological time points, indicating retarded bone growth (J:121780)
• stigmata of abnormal cortical growth remains at 4 weeks of age (J:121780)

craniofacial
• hyperteloric with narrower, taller skulls (J:121780)
• overall skull lengths are decreased and about 10% shorter by 12 weeks of age (J:121780)
• area between the right and left frontal-squamosal intersection at the temporal crest, mid-cranial width, is wider and this difference increases with age (J:121780)
• mid-cranial width differences continue to increase from about 10% at 4 weeks to nearly 25% at 24 weeks (J:121780)
• hyperteloric with narrower, taller skulls (J:121780)
• overall skull lengths are decreased and about 10% shorter by 12 weeks of age (J:121780)
• area between the right and left frontal-squamosal intersection at the temporal crest, mid-cranial width, is wider and this difference increases with age (J:121780)
• mid-cranial width differences continue to increase from about 10% at 4 weeks to nearly 25% at 24 weeks (J:121780)
• coronal sutures are prominent and sclerotic (J:121780)
• coronal sutures are prominent and sclerotic (J:121780)
• lambdoid sutures are prominent and sclerotic (J:121780)
• lambdoid sutures are prominent and sclerotic (J:121780)
• sagittal sutures are prominent and sclerotic (J:121780)
• sagittal sutures are prominent and sclerotic (J:121780)
• lower jaw length is about 10% shorter by 12 weeks of age (J:121780)
• lower jaw length is about 10% shorter by 12 weeks of age (J:121780)
• upper jaw length is about 10% shorter by 12 weeks of age (J:121780)
• upper jaw length is about 10% shorter by 12 weeks of age (J:121780)
• broad snout (J:121780)
• broad snout (J:121780)
• snouts are about 15% shorter than wild-type at 4 weeks of age (J:121780)
• snouts are about 15% shorter than wild-type at 4 weeks of age (J:121780)

growth/size/body
• broad snout (J:121780)
• broad snout (J:121780)
• snouts are about 15% shorter than wild-type at 4 weeks of age (J:121780)
• snouts are about 15% shorter than wild-type at 4 weeks of age (J:121780)

hematopoietic system
• bone marrow has transiently decreased osteoclast numbers (J:121780)
• osteoblast and osteoclast numbers per trabecular bone surface area are decreased by more than half at 4 days of age, but no differences are seen at 4 and 12 weeks of age, indicating a transient decrease (J:121780)
• bone marrow has transiently decreased osteoclast numbers (J:121780)
• osteoblast and osteoclast numbers per trabecular bone surface area are decreased by more than half at 4 days of age, but no differences are seen at 4 and 12 weeks of age, indicating a transient decrease (J:121780)
• 60% decrease in the number of proliferating cells in the bone marrow at 4 days of age but not at 4 or 12 weeks of age (J:121780)
• bone marrow stromal cells and calvaria are unable to support osteoblast and osteoclast growth ex vivo (J:121780)
• 60% decrease in the number of proliferating cells in the bone marrow at 4 days of age but not at 4 or 12 weeks of age (J:121780)
• bone marrow stromal cells and calvaria are unable to support osteoblast and osteoclast growth ex vivo (J:121780)

immune system
• bone marrow has transiently decreased osteoclast numbers (J:121780)
• osteoblast and osteoclast numbers per trabecular bone surface area are decreased by more than half at 4 days of age, but no differences are seen at 4 and 12 weeks of age, indicating a transient decrease (J:121780)
• bone marrow has transiently decreased osteoclast numbers (J:121780)
• osteoblast and osteoclast numbers per trabecular bone surface area are decreased by more than half at 4 days of age, but no differences are seen at 4 and 12 weeks of age, indicating a transient decrease (J:121780)
• femoral condyles and proximal tibiae show cartilage destruction with erosions of cartilage occupied by fibrous tissue and inflammatory cells (J:121780)
• femoral condyles and proximal tibiae show cartilage destruction with erosions of cartilage occupied by fibrous tissue and inflammatory cells (J:121780)

vision/eye
• mice exhibit 35% less ischemia-induced retinal neovascularization compared with similarly treated wild-type mice (J:113620)
• mice exhibit 35% less ischemia-induced retinal neovascularization compared with similarly treated wild-type mice (J:113620)
• intercanthal distances are increased by about 10% at 4 weeks of age, however by 12 weeks of age, they are no longer statistically different (J:121780)
• intercanthal distances are increased by about 10% at 4 weeks of age, however by 12 weeks of age, they are no longer statistically different (J:121780)

Mouse Models of Human Disease
OMIM ID Ref(s)
Multicentric Osteolysis, Nodulosis, and Arthropathy; MONA 259600 J:121780


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory