Phenotypes for Rho MGI:4367269 MGI Mouse

vision/eye

abnormal retina vasculature morphology ( J:153281 )

• attenuated retinal blood vessels are observed in photographs of the fundus at postnatal day (P) 21

short photoreceptor outer segment ( J:153281 )

• examination of the retinal ultrastructure by transmission electron microscopy (TEM) reveals short outer segments with disorganized discs at P21

abnormal retina pigmentation ( J:153281 )

• unevenly distributed pigment patches are observed in photographs of the fundus at P21

abnormal retina inner nuclear layer morphology ( J:153281 )

• immunohistochemical analysis at P14 reveals the mutant rhodopsin protein accumulating in the photoreceptor inner segments and/or cell bodies instead of trafficking to the photoreceptor outer segments

retina outer nuclear layer degeneration ( J:153281 )

• the outer nuclear layer (ONL) of the retina is reduced by 50% by P18 and consists of only two rows of nuclei by P35

retina degeneration ( J:153281 )

• rapidly progressive

abnormal eye electrophysiology ( J:153281 )

• whole field scotopic electroretinography at P21 demonstrates severely reduced photoreceptor cell function: both a- and b-waves are severely attenuated, the a-wave amplitude reduced to approximately one-third that of wild-type mice

cardiovascular system