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Phenotypes Associated with This Genotype
Genotype
MGI:4367269
Allelic
Composition
RhoR3/Rho+
Genetic
Background
C57BL/6J-RhoR3
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
RhoR3 mutation (0 available); any Rho mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• attenuated retinal blood vessels are observed in photographs of the fundus at postnatal day (P) 21
• examination of the retinal ultrastructure by transmission electron microscopy (TEM) reveals short outer segments with disorganized discs at P21
• unevenly distributed pigment patches are observed in photographs of the fundus at P21
• immunohistochemical analysis at P14 reveals the mutant rhodopsin protein accumulating in the photoreceptor inner segments and/or cell bodies instead of trafficking to the photoreceptor outer segments
• the outer nuclear layer (ONL) of the retina is reduced by 50% by P18 and consists of only two rows of nuclei by P35
• rapidly progressive
• whole field scotopic electroretinography at P21 demonstrates severely reduced photoreceptor cell function: both a- and b-waves are severely attenuated, the a-wave amplitude reduced to approximately one-third that of wild-type mice

cardiovascular system
• attenuated retinal blood vessels are observed in photographs of the fundus at postnatal day (P) 21

pigmentation
• unevenly distributed pigment patches are observed in photographs of the fundus at P21

nervous system
• examination of the retinal ultrastructure by transmission electron microscopy (TEM) reveals short outer segments with disorganized discs at P21

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
retinitis pigmentosa 4 DOID:0110372 OMIM:613731
J:153281


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory