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Phenotypes Associated with This Genotype
Genotype
MGI:4367083
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Tg(APOC3)3707Bres/?
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (47 available)
Tg(APOC3)3707Bres mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• DL-LDL levels increased about 2 fold over the 32mg/dl level found in mice carrying only the transgene
• 3-4 fold increase in IDL-LDL on a Western diet over the 86mg/dl level found in mice carrying only the transgene but also on a Western diet
• increased 10 fold over the level of 50mg/dl or less found in mice carrying only the transgene
• more pronounced increase when fed a Western diet

cardiovascular system
• lesions at the base of the aorta are 2-3 times the size of lesions in mice lacking the transgene but homozygous for Ldlr deficiency

Mouse Models of Human Disease
OMIM ID Ref(s)
Hyperlipidemia, Familial Combined; FCHL 144250 J:37861


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory