Mouse Genome Informatics
cx
    Ldlrtm1Her/Ldlrtm1Her
Tg(APOC3)3707Bres/?

involves: 129S7/SvEvBrd * C57BL/6J * CBA/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• DL-LDL levels increased about 2 fold over the 32mg/dl level found in mice carrying only the transgene
• 3-4 fold increase in IDL-LDL on a Western diet over the 86mg/dl level found in mice carrying only the transgene but also on a Western diet
• increased 10 fold over the level of 50mg/dl or less found in mice carrying only the transgene
• more pronounced increase when fed a Western diet

cardiovascular system
• lesions at the base of the aorta are 2-3 times the size of lesions in mice lacking the transgene but homozygous for Ldlr deficiency

Mouse Models of Human Disease
OMIM IDRef(s)
Hyperlipidemia, Familial Combined; FCHL 144250 J:37861