Phenotypes Associated with This Genotype

Genotype
MGI:4367083

• Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her; Tg(APOC3)3707Bres/?
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating LDL cholesterol level ( J:37861 )

• DL-LDL levels increased about 2 fold over the 32mg/dl level found in mice carrying only the transgene

• 3-4 fold increase in IDL-LDL on a Western diet over the 86mg/dl level found in mice carrying only the transgene but also on a Western diet

increased circulating VLDL cholesterol level ( J:37861 )

• increased 10 fold over the level of 50mg/dl or less found in mice carrying only the transgene

• more pronounced increase when fed a Western diet

cardiovascular system

atherosclerotic lesions ( J:37861 )

• lesions at the base of the aorta are 2-3 times the size of lesions in mice lacking the transgene but homozygous for Ldlr deficiency

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial combined hyperlipidemia		DOID:13809	OMIM:144250	J:37861