Phenotypes Associated with This Genotype

Genotype
MGI:4366920

• Allelic Composition: Pold1^tm1.1Bdp/Pold1^tm1.1Bdp
• Genetic Background: B6.129-Pold1^tm1.1Bdp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:153684 )

• mice die before 15 months

neoplasm

increased intestinal adenocarcinoma incidence ( J:153684 )

• 14% of mice develop intestinal adenomas and adenocarcinomas compared with 5% of wild-type mice

increased intestinal adenoma incidence ( J:153684 )

• 14% of mice develop intestinal adenomas and adenocarcinomas compared with 5% of wild-type mice

increased skin tumor incidence ( J:153684 )

• 25% of mice develop tail skin squamous cell neoplasms (papilloma or carcinoma) unlike wild-type mice

increased lymphoma incidence ( J:153684 )

• 14% of mice develop nodal lymphomas compared with 6% of wild-type mice

increased T cell derived lymphoma incidence ( J:153684 )

• in 42% of mice unlike wild-type mice

increased lung tumor incidence ( J:153684 )

• 28% of mice develop lung adenomas and adenocarcinomas compared with 9% of wild-type mice

integument

increased skin tumor incidence ( J:153684 )

• 25% of mice develop tail skin squamous cell neoplasms (papilloma or carcinoma) unlike wild-type mice

digestive/alimentary system

increased intestinal adenocarcinoma incidence ( J:153684 )

• 14% of mice develop intestinal adenomas and adenocarcinomas compared with 5% of wild-type mice

increased intestinal adenoma incidence ( J:153684 )

• 14% of mice develop intestinal adenomas and adenocarcinomas compared with 5% of wild-type mice

respiratory system

increased lung tumor incidence ( J:153684 )

• 28% of mice develop lung adenomas and adenocarcinomas compared with 9% of wild-type mice

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:153684 )

• in 42% of mice unlike wild-type mice