Phenotypes Associated with This Genotype

Genotype
MGI:4366866

• Allelic Composition: Cebpb^tm3Nerl/Cebpb^tm3Nerl
• Genetic Background: either: B6.129P2-Cebpb^tm3Nerl or (involves: 129P2/OlaHsd * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

myositis ( J:153686 )

• 5 days after treatment with cardiotoxin, mice exhibit increased muscle inflammation compared with similarly treated wild-type mice

decreased skeletal muscle fiber size ( J:153686 )

• following treatment with cardiotoxin, regenerating myofibers are smaller with decreased cross-sectional area and a 20% reduction in total regenerated area compared with myofibers in similarly treated wild-type mice

skeletal muscle fibrosis ( J:153686 )

• 10 days after treatment with cardiotoxin, mice exhibit muscle fibrosis unlike similarly treated mice whose injury is largely resolved

calcified muscle ( J:153686 )

impaired skeletal muscle regeneration ( J:153686 )

• following treatment with cardiotoxin, mice exhibit reduced muscle regeneration compared with similarly treated wild-type mice

• defective muscle regeneration of cardiotoxin-induced muscle damage is observed when bone marrow is transplanted into wild-type mice

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:153686 )

• 5 days after treatment with cardiotoxin, mice exhibit increased muscle inflammation compared with similarly treated wild-type mice

• 10 days after treatment with cardiotoxin, mice exhibit muscle fibrosis multifocal areas of inflammation, and severely calcified myofiber unlike similarly treated mice whose injury is largely resolved

• following treatment with cardiotoxin, regenerating myofibers are smaller with decreased cross-sectional area and a 20% reduction in total regenerated area compared with myofibers in similarly treated wild-type mice

• following treatment with cardiotoxin, mice exhibit reduced muscle regeneration compared with similarly treated wild-type mice

• defective muscle regeneration of cardiotoxin-induced muscle damage is observed when bone marrow is transplanted into wild-type mice

immune system

myositis ( J:153686 )

• 5 days after treatment with cardiotoxin, mice exhibit increased muscle inflammation compared with similarly treated wild-type mice

reproductive system

reproductive system phenotype ( J:153686 )

N • unlike Cebpb^tm1Pfj homozygotes, mice are fertile and lactate