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Phenotypes Associated with This Genotype
Genotype
MGI:4366780
Allelic
Composition
Nos1tm1Plh/Nos1tm1Plh
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nos1tm1Plh mutation (3 available); any Nos1 mutation (50 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• diffuse enlargement

renal/urinary system
• increase in urine bicarbonate concentration
• increase in urine pH
• the rate of bicarbonate absorption is reduced in the proximal tubules
• the rate of net fluid absorption is reduced in the proximal tubules

cardiovascular system
• atria display higher baseline heart rates
• decrease in heart rate in response to vagal nerve stimulation is slower

homeostasis/metabolism
N
• despite differences in behavioral responses to alcohol, no differences in blood alcohol elimination are detected
• the rate of net fluid absorption is reduced in the proximal tubules
• increase in urine bicarbonate concentration
• arterial blood pH and bicarbonate concentrations are reduced resulting in a modest but significant metabolic acidosis
• increase in urine pH

behavior/neurological
• mice consume more alcohol when presented with solutions containing high concentrations of alcohol (greater than 8% alcohol) compared to wild-type controls
• however, when presented with dilute solutions of alcohol (2 - 4%), alcohol consumption does not differ from controls
• following dosing with 2.5 or 4.5 gm/kg mice regain their righting reflex faster compared to similarly treated wild-type controls
• mice fail to develop tolerance to alcohol induced hypothermia following multiple ethanol injection
• impaired performance during memory recall trials in a Morris water maze
• however, performance in the less stressful multiple T maze is improved compared to controls
• the concentration dependent increase in sucrose preference is more pronounced in mutants compared to wild-type controls
• however, the concentration dependent aversion to quinine is not significantly different from controls
• Background Sensitivity: unlike mice on a congenic C57BL/6J background, male mice display increased aggression
• Background Sensitivity: mice display increased aggression compared to C57BL/6J mice but not compared to 129S2/SvPas mice
• in a forced swim test mice spend more time actively swimming and less time immobile compared to wild-type controls
• increase in grooming behavior is seen in mice in an open field and during an elevated plus maze assay suggesting an increase in the amount of stress mice experience under these conditions
• seen in mice in an open field and during an elevated plus maze assay suggesting an increase in the amount of stress mice experience under these conditions
• in the last trial mice spend more time on the rotarod compared to wild-type controls

digestive/alimentary system
N
• unlike in human patients with Infantile Hypertrophic Pyloric Stenosis, the luminal aperture of the pyloric sphincter is not significantly smaller in relaxed tissues compared to wild type controls
• diffuse enlargement
• diffuse enlargement
• pyloric sphincter thickness is increased by 17% compared to controls
• diffuse enlargement
• weight and volume are increased
• muscular thickening is seen throughout the stomach
• stomachs often contain bezoars even after 2 days of fasting
• gastric emptying of solids and liquids is delayed

muscle
• pyloric sphincter thickness is increased by 17% compared to controls


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory