Phenotypes Associated with This Genotype

Genotype
MGI:4366519

• Allelic Composition: Dnm1l^tm1.2Hise/Dnm1l^tm1.2Hise
• Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Small size and internal hemorrhage in Dnm1l^tm1.2Hise/Dnm1l^tm1.2Hise embryos

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:153835 )

• no viable mice are present at E11.5

cellular

abnormal mitochondrial morphology ( J:153835 )

• mouse embryonic fibroblasts contain highly connected, elongated mitochondrial tubules unlike wild-type cells

decreased apoptosis ( J:153835 )

• E9.5 and E10.5, neural tubes exhibit less apoptosis than in wild-type mice

• however, mouse embryonic fibroblasts exhibit normal levels of induced apoptosis in vitro

decreased fibroblast proliferation ( J:153835 )

• in mouse embryonic fibroblasts

cardiovascular system

internal hemorrhage ( J:153835 )

• at E11.5

abnormal myocardial fiber physiology ( J:153835 )

• isolated cardiomyocytes from E10.5 mice exhibit decreased beating rates compared with cells from E9.5 and E10.5 wild-type mice

embryo

decreased embryo size ( J:153835 )

• at E9.5, E10.5, and E11.5

absent trophoblast giant cells ( J:153835 )

growth/size/body

decreased embryo size ( J:153835 )

• at E9.5, E10.5, and E11.5