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Phenotypes Associated with This Genotype
Genotype
MGI:4365946
Allelic
Composition
Ts(1716)65Dn/0
Genetic
Background
B6EiC3Sn.BLiA-Ts(1716)65Dn/DnJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ts(1716)65Dn mutation (2 available); any Ts(1716)65Dn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• the length from the nost to the tip of the tail is shorter than in background controls, although the length from the nose to the base of the tail does not have a statistically significant difference

behavior/neurological
• in 22 degree water there is increased latency of acquisition of the hidden platform in the Morris water maze test
• output of a grip strength meter shows reduced grip force relative to controls
• significantly increased dark cycle rearing
• although activity during the light cycle is not different from that of controls, during the dark cycle the total activity is significantly greater than in background controls
• significantly increased dark cycle horizontal and vertical stereotypic activity

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Down syndrome DOID:14250 OMIM:190685
J:153579


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory