Phenotypes Associated with This Genotype

Genotype
MGI:4365406

• Allelic Composition: Gpr55^tm1.1Mijr/Gpr55^tm1.1Mijr
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal osteoclast morphology ( J:153225 )

• osteoclasts in male mice appear plump and inactive unlike in wild-type mice

abnormal osteoclast differentiation ( J:153225 )

• O-1602 fails to inhibit osteoclast formation as in wild-type mice

decreased osteoclast cell number ( J:153225 )

• in female mice

increased osteoclast cell number ( J:153225 )

• in male mice

abnormal osteoclast physiology ( J:153225 )

• male mice exhibit an increase in osteoclast surface but an impairment in osteoclast function compared to in wild-type mice

• osteoclasts in male mice appear plump and inactive unlike in wild-type mice

• male and female mice exhibit an increase in unresorbed cartilage compared to in wild-type mice

• in female mice the osteoclast surface as a percent of bone surface is decreased compared to in wild-type mice

increased bone volume ( J:153225 )

• at 12 weeks, bone volume in male mice is increased in the femur and tibia compared to in wild-type mice

• however, female mice exhibit normal bone mass

abnormal trabecular bone morphology ( J:153225 )

• at 12 weeks, male mice exhibit increased trabecular number, trabecular connectivity, trabecular bone volume to total volume, and transition from rod-like to plate-like trabecular structure with a reduction in trabecular separation compared to in wild-type mice

• however, female mice exhibit normal bone morphology

homeostasis/metabolism

abnormal physiological response to xenobiotic ( J:153225 )

• O-1602 fails to inhibit osteoclast formation as in wild-type mice

immune system

abnormal osteoclast morphology ( J:153225 )

• osteoclasts in male mice appear plump and inactive unlike in wild-type mice

abnormal osteoclast differentiation ( J:153225 )

• O-1602 fails to inhibit osteoclast formation as in wild-type mice

decreased osteoclast cell number ( J:153225 )

• in female mice

increased osteoclast cell number ( J:153225 )

• in male mice

abnormal osteoclast physiology ( J:153225 )

• male mice exhibit an increase in osteoclast surface but an impairment in osteoclast function compared to in wild-type mice

• osteoclasts in male mice appear plump and inactive unlike in wild-type mice

• male and female mice exhibit an increase in unresorbed cartilage compared to in wild-type mice

• in female mice the osteoclast surface as a percent of bone surface is decreased compared to in wild-type mice

hematopoietic system

abnormal osteoclast morphology ( J:153225 )

• osteoclasts in male mice appear plump and inactive unlike in wild-type mice

abnormal osteoclast differentiation ( J:153225 )

• O-1602 fails to inhibit osteoclast formation as in wild-type mice

decreased osteoclast cell number ( J:153225 )

• in female mice

increased osteoclast cell number ( J:153225 )

• in male mice

abnormal osteoclast physiology ( J:153225 )

• male mice exhibit an increase in osteoclast surface but an impairment in osteoclast function compared to in wild-type mice

• osteoclasts in male mice appear plump and inactive unlike in wild-type mice

• male and female mice exhibit an increase in unresorbed cartilage compared to in wild-type mice

• in female mice the osteoclast surface as a percent of bone surface is decreased compared to in wild-type mice

cellular

abnormal osteoclast differentiation ( J:153225 )

• O-1602 fails to inhibit osteoclast formation as in wild-type mice