Phenotypes Associated with This Genotype

Genotype
MGI:4365401

• Allelic Composition: Ern1^tm1Tiw/Ern1^tm1Tiw
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:153222 )

• begin to die around E12.5

embryo

decreased embryo size ( J:153222 )

• at E13.5

abnormal placenta labyrinth morphology ( J:153222 )

• severely disrupted at E13.5

abnormal placental labyrinth vasculature morphology ( J:153222 )

• reduction in the internal space of embryonic and maternal blood vessels at E13.5

small placenta ( J:153222 )

• at E13.5

abnormal trophoblast layer morphology ( J:153222 )

• at E13.5 trophoblasts display poor ER development

abnormal extraembryonic tissue physiology ( J:153222 )

• expression analysis suggests that ER stress may be increased in the placenta

• placental trophoblasts display reduced proliferation at E13.5

• however, apoptosis of trophoblasts is not different from controls

abnormal placental transport ( J:153222 )

• lower embryonic levels of 3 essential fatty acids but not of non essential fatty acids suggests that placental transport is impaired

growth/size/body

decreased embryo size ( J:153222 )

• at E13.5

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:153222 )

• reduction in the internal space of embryonic and maternal blood vessels at E13.5