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Phenotypes Associated with This Genotype
Genotype
MGI:4361924
Allelic
Composition
Tg(MMTV-PyVT)634Mul/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTV-PyVT)634Mul mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• average onset of tumor development is 66 days (J:133325)
• tumor nodules are present throughout the entire mammary gland (J:133325)
• extensive adenomas are found (J:133325)
• primary tumors are highly fibrotic (J:236031)
• tumors exhibit more linear, thicker collagen fibers consistent with aggressive and invasive tumors (J:236031)
• tumors have higher CD31 staining, indicating increased primary tumor vasculature (J:236031)

endocrine/exocrine glands
• tumor nodules are present throughout the entire mammary gland
• average onset of tumor development is 66 days (J:133325)
• tumor nodules are present throughout the entire mammary gland (J:133325)
• extensive adenomas are found (J:133325)
• primary tumors are highly fibrotic (J:236031)
• tumors exhibit more linear, thicker collagen fibers consistent with aggressive and invasive tumors (J:236031)
• tumors have higher CD31 staining, indicating increased primary tumor vasculature (J:236031)

integument
• tumor nodules are present throughout the entire mammary gland
• average onset of tumor development is 66 days (J:133325)
• tumor nodules are present throughout the entire mammary gland (J:133325)
• extensive adenomas are found (J:133325)
• primary tumors are highly fibrotic (J:236031)
• tumors exhibit more linear, thicker collagen fibers consistent with aggressive and invasive tumors (J:236031)
• tumors have higher CD31 staining, indicating increased primary tumor vasculature (J:236031)

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
J:236031


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory