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Phenotypes Associated with This Genotype
Genotype
MGI:4361196
Allelic
Composition
Tg(Krt19-Ptgs2,Krt19-Ptges)8Tko/0
Tg(Krt19-Wnt1)2Maos/0
Genetic
Background
involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• 100% penetrance of dysplastic gastric tumors in mice older than 20 weeks of age, with tumors consisting of dysplastic epithelial cells with nuclear stratification and irregularly branched tubules (J:116782)
• tumors resemble human intestinal-type gastric cancer and gastric adenocarcinoma (J:116782)
• tumor invasion into the smooth muscle layers is seen in 50%, 75% and 100% of mutants at 20, 30, and 50 weeks of age, respectively (J:116782)
• tumors exhibit an accumulation of macrophages and increased angiogenesis (J:116782)

digestive/alimentary system
• hyperproliferation of gastric epithelial cells
• mutants exhibit mucous metaplasia as early as 5 weeks of age, before dysplastic tumor formation
• 100% penetrance of dysplastic gastric tumors in mice older than 20 weeks of age, with tumors consisting of dysplastic epithelial cells with nuclear stratification and irregularly branched tubules (J:116782)
• tumors resemble human intestinal-type gastric cancer and gastric adenocarcinoma (J:116782)
• tumor invasion into the smooth muscle layers is seen in 50%, 75% and 100% of mutants at 20, 30, and 50 weeks of age, respectively (J:116782)
• tumors exhibit an accumulation of macrophages and increased angiogenesis (J:116782)

mortality/aging
• some mice die between 25 and 50 weeks of age due to tumors

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
stomach cancer DOID:10534 OMIM:137215
OMIM:613659
J:116782


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory