Mouse Genome Informatics
cx
    Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-PLAGL2)P3Ysy/0

involves: FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
respiratory system
• doxycycline-treated mice develop centrilobular emphysema and in severe cases such mice exhibit total destruction of an entire lobe
• 90% of doxycycline-treated female mice develop emphysema
• doxycycline-treated female mice exhibit a shift in the inspiratory pressure volume curve to the left indicating an increase in respiratory system compliance compared with wild-type mice

cellular
• doxycycline-treated mice exhibit an increase in apoptosis in the peripheral airway epithelial cells adjacent to the emphysematous lesions

Mouse Models of Human Disease
OMIM IDRef(s)
Emphysema, Hereditary Pulmonary 130700 J:152422