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Phenotypes Associated with This Genotype
Genotype
MGI:4360917
Allelic
Composition
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-PLAGL2)P3Ysy/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(SFTPC-rtTA)5Jaw mutation (3 available)
Tg(tetO-PLAGL2)P3Ysy mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• doxycycline-treated mice develop centrilobular emphysema and in severe cases such mice exhibit total destruction of an entire lobe
• 90% of doxycycline-treated female mice develop emphysema
• doxycycline-treated female mice exhibit a shift in the inspiratory pressure volume curve to the left indicating an increase in respiratory system compliance compared with wild-type mice

cellular
• doxycycline-treated mice exhibit an increase in apoptosis in the peripheral airway epithelial cells adjacent to the emphysematous lesions

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
pulmonary emphysema DOID:9675 OMIM:130700
J:152422


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory