Phenotypes Associated with This Genotype

Genotype
MGI:4360917

• Allelic Composition: Tg(SFTPC-rtTA)5Jaw/0; Tg(tetO-PLAGL2)P3Ysy/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

emphysema ( J:152422 )

• doxycycline-treated mice develop centrilobular emphysema and in severe cases such mice exhibit total destruction of an entire lobe

• 90% of doxycycline-treated female mice develop emphysema

abnormal respiratory function ( J:152422 )

• doxycycline-treated female mice exhibit a shift in the inspiratory pressure volume curve to the left indicating an increase in respiratory system compliance compared with wild-type mice

cellular

increased apoptosis ( J:152422 )

• doxycycline-treated mice exhibit an increase in apoptosis in the peripheral airway epithelial cells adjacent to the emphysematous lesions

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pulmonary emphysema		DOID:9675	OMIM:130700	J:152422