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Phenotypes Associated with This Genotype
Genotype
MGI:4360798
Allelic
Composition
Tg(RBP3-ELOVL4*)3Kzh/0
Genetic
Background
C57BL/6-Tg(RBP3-ELOVL4*)3Kzh
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• abnormalities are more evident as expression levels of the transgene increase in the three lines created (J:97173)
• abnormalities are more evident as expression levels of the transgene increase in the three lines created (J:97173)
• mice exhibit localized regions of the retina that appear lighter because of depigmentation in areas of retinal pigment epithelium atrophy and photoreceptor degeneration (J:97173)
• mice exhibit localized regions of the retina that appear lighter because of depigmentation in areas of retinal pigment epithelium atrophy and photoreceptor degeneration (J:97173)
• as early as 3 weeks, the photoreceptor outer segment is severely stunted with disks clustered in groups instead of stacked as in wild-type mice (J:97173)
• as early as 3 weeks, the photoreceptor outer segment is severely stunted with disks clustered in groups instead of stacked as in wild-type mice (J:97173)
• at 6 weeks, 50% of photoreceptor in the outer nuclear layer are degenerated (J:97173)
• at 6 weeks, 50% of photoreceptor in the outer nuclear layer are degenerated (J:97173)
• more severe in the center of the retina (J:97173)
• more severe in the center of the retina (J:97173)
• retinal degeneration is progressive, localized, and more severe in the center of the retina (J:97173)
• retinal degeneration is more severe than in other lines over expressing the same transgene (J:97173)
• retinal degeneration is progressive, localized, and more severe in the center of the retina (J:97173)
• retinal degeneration is more severe than in other lines over expressing the same transgene (J:97173)
• at rod-saturation, cone b-wave declines in amplitude compared to in wild-type mice (J:97173)
• at rod-saturation, cone b-wave declines in amplitude compared to in wild-type mice (J:97173)
• rod b-wave response is reduced at 22 weeks and absent at 22 weeks (J:97173)
• rod b-wave response is reduced at 22 weeks and absent at 22 weeks (J:97173)

nervous system
• as early as 3 weeks, the photoreceptor outer segment is severely stunted with disks clustered in groups instead of stacked as in wild-type mice (J:97173)
• as early as 3 weeks, the photoreceptor outer segment is severely stunted with disks clustered in groups instead of stacked as in wild-type mice (J:97173)
• at 6 weeks, 50% of photoreceptor in the outer nuclear layer are degenerated (J:97173)
• at 6 weeks, 50% of photoreceptor in the outer nuclear layer are degenerated (J:97173)

pigmentation
• more severe in the center of the retina (J:97173)
• more severe in the center of the retina (J:97173)

Mouse Models of Human Disease
OMIM ID Ref(s)
Stargardt Disease 3; STGD3 600110 J:97173


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory