Phenotypes Associated with This Genotype

Genotype
MGI:4360683

• Allelic Composition: Atn1^tm1Rexu/Atn1^tm1Rexu
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:152709 )

• shorter average life span (90 weeks)

postnatal lethality, incomplete penetrance ( J:152709 )

• viable at birth with expected Mendelian ratios

• approximately 30% die before weaning

growth/size/body

decreased body weight ( J:152709 )

• newborn have normal body weight

• approximately 20% lighter by the age of weaning

• low body weight persists through puberty and adulthood

• can not be rescued by a neuron specific wild-type human Atrophin-1 transgene Tg(Eno2-ATN1)1Tx

behavior/neurological

decreased food intake ( J:152709 )

• adult mice consume less food

• normal rotarod test results

reproductive system

small testis ( J:152709 )

♂ • in 5 of 8 mice

♂ • apoptotic cells frequently found

♂ • degeneration in aged mice

abnormal sperm number ( J:152709 )

♂ • low sperm counts in testes and epididymis

♂ • apoptosis frequently observed in aged mutant testis

reduced male fertility ( J:152709 )

♂ • gradually lose fertility and became sterile at the age around eight months

nervous system

nervous system phenotype ( J:152709 )

N • normal brain structure and morphology

N • no neurodegeneration

endocrine/exocrine glands

small testis ( J:152709 )

♂ • in 5 of 8 mice

♂ • apoptotic cells frequently found

♂ • degeneration in aged mice