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Phenotypes Associated with This Genotype
Genotype
MGI:4360543
Allelic
Composition
Grin2atm1Nak/Grin2atm1Nak
Grin2ctm1Nak/Grin2ctm1Nak
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin2atm1Nak mutation (7 available); any Grin2a mutation (44 available)
Grin2ctm1Nak mutation (1 available); any Grin2c mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• no gross anatomical changes in the brain; the organization of the cerebellum is unaltered and the size and density of the granule cells is similar in mutant and control mice
• evoked ESPCs are absent in cerebellar granule cells in double mutant mice
• the amplitude of the slow component (characteristic of NMDA receptor activity) of spontaneous ESPCs in cerebellar granule cells is nearly absent in mutant mice compared to controls

behavior/neurological
N
• mutant mice do not exhibit ataxia or tremors, and grip strength and righting reflex is similar to controls
• double mutant mice do not maintain balance and cannot stand or walk on a 6mm wide fixed bar while control mice can walk smoothly and stay on the bar
• on a 20mm fixed bar, mutant mice can can walk smoothly and stay on the bar, similar to controls
• on a rotating rod at 25 rpm, mutant mice fail to stay on the rod and do not improve performance with training
• at 10 and 20 rpm, mutant mice perform similar to controls
• the amount of rearing activity is significantly reduced in mutant mice compared to controls
• there is no difference in horizontal locomotor activity compared to controls


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/05/2019
MGI 6.14
The Jackson Laboratory