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Phenotypes Associated with This Genotype
Genotype
MGI:4360542
Allelic
Composition
Grin2atm1Nak/Grin2atm1Nak
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin2atm1Nak mutation (7 available); any Grin2a mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• no gross anatomical changes in the brain; the organization of the cerebellum is unaltered and the size and density of the granule cells is similar in mutant and control mice
• the rise time in evoked ESPCs is simutant mice do not exhibit impaired coordination in the fixed bar or rotarod test similar in mutant mice compared to controls, but the decay time is slower in mutant mice; the time constants of both fast and slow components of decay increased in mutant mice compared to controls
• the amplitude of the slow component (characteristic of NMDA receptor activity) of spontaneous ESPCs in cerebellar granule cells is reduced by approximately half in mutant mice compared to controls

behavior/neurological
N
• mutant mice do not exhibit ataxia or tremors, and grip strength and righting reflex is similar to controls
• mutant mice do not exhibit impaired coordination in the fixed bar or rotarod tests
• the amount of rearing activity is slightly reduced in mutant mice compared to controls
• there is no difference in horizontal locomotor activity compared to controls


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/05/2019
MGI 6.14
The Jackson Laboratory