Phenotypes Associated with This Genotype

Genotype
MGI:4360542

• Allelic Composition: Grin2a^tm1Nak/Grin2a^tm1Nak
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:66455 )

N • no gross anatomical changes in the brain; the organization of the cerebellum is unaltered and the size and density of the granule cells is similar in mutant and control mice

abnormal excitatory postsynaptic currents ( J:66455 )

• the rise time in evoked ESPCs is simutant mice do not exhibit impaired coordination in the fixed bar or rotarod test similar in mutant mice compared to controls, but the decay time is slower in mutant mice; the time constants of both fast and slow components of decay increased in mutant mice compared to controls

abnormal miniature excitatory postsynaptic currents ( J:66455 )

• the amplitude of the slow component (characteristic of NMDA receptor activity) of spontaneous ESPCs in cerebellar granule cells is reduced by approximately half in mutant mice compared to controls

behavior/neurological

behavior/neurological phenotype ( J:66455 )

N • mutant mice do not exhibit ataxia or tremors, and grip strength and righting reflex is similar to controls

N • mutant mice do not exhibit impaired coordination in the fixed bar or rotarod tests

decreased vertical activity ( J:66455 )

• the amount of rearing activity is slightly reduced in mutant mice compared to controls

• there is no difference in horizontal locomotor activity compared to controls