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Phenotypes Associated with This Genotype
Genotype
MGI:4360179
Allelic
Composition
Tg(Ins2-CALM1)26Ove/0
Genetic
Background
FVB-Tg(Ins2-CALM1)26Ove
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Mouse lines carrying:
Tg(Ins2-CALM1)26Ove mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• swollen mitochondria and broken mitochondrial double membranes are observed (J:106851)
• hearts have increased mitochondrial mass, as well as greater area and number (J:106851)
• swollen mitochondria and broken mitochondrial double membranes are observed (J:106851)
• hearts have increased mitochondrial mass, as well as greater area and number (J:106851)
• respiratory control ratio (RCR) and state 3 respiration are significantly impaired in mitochondria (J:106851)
• respiratory control ratio (RCR) and state 3 respiration are significantly impaired in mitochondria (J:106851)

cardiovascular system
• hearts have many focal areas of damage with swollen mitochondria, mottled matrix and broken mitochondrial double membranes (J:106851)
• hearts have many focal areas of damage with swollen mitochondria, mottled matrix and broken mitochondrial double membranes (J:106851)
• progressive increase in renal vascular resistance beginning at 3 months of age (J:94602)
• progressive increase in renal vascular resistance beginning at 3 months of age (J:94602)
• diastolic blood pressure is elevated in conscious mutants at 3 months of age when measured using a tail-cuff monitor (J:94602)
• by 8 months of age, both diastolic and systolic blood pressure is increased in conscious mutants (J:94602)
• under anesthesia, when measured by intravascular connulation, mutants exhibit a similar blood pressure to anesthetized controls, however this is reduced compared to conscious mutants (J:94602)
• diastolic blood pressure is elevated in conscious mutants at 3 months of age when measured using a tail-cuff monitor (J:94602)
• by 8 months of age, both diastolic and systolic blood pressure is increased in conscious mutants (J:94602)
• under anesthesia, when measured by intravascular connulation, mutants exhibit a similar blood pressure to anesthetized controls, however this is reduced compared to conscious mutants (J:94602)

homeostasis/metabolism
• blood glucose levels are more than 2-fold higher than normal by 20 days after birth and continue to rise until at least 60 days of age (J:94602)
• blood glucose levels are more than 2-fold higher than normal by 20 days after birth and continue to rise until at least 60 days of age (J:94602)
• some mutants develop hypoalbuminemia due to excessive loss of albumin (J:94602)
• some mutants develop hypoalbuminemia due to excessive loss of albumin (J:94602)
• albumin excretion rate increases progressively with age and exceeds 15,000 ug/24 hr at 9 months of age (J:94602)
• albumin excretion rate increases progressively with age and exceeds 15,000 ug/24 hr at 9 months of age (J:94602)

adipose tissue
• loss of fat tissue by 5 months of age (J:94602)
• loss of fat tissue by 5 months of age (J:94602)

growth/size/body
N
• mutants exhibit normal weight gain and body weight (J:94602)
• mutants exhibit normal weight gain and body weight (J:94602)

liver/biliary system

renal/urinary system
• progressive increase in renal vascular resistance beginning at 3 months of age (J:94602)
• progressive increase in renal vascular resistance beginning at 3 months of age (J:94602)
• albumin excretion rate increases progressively with age and exceeds 15,000 ug/24 hr at 9 months of age (J:94602)
• albumin excretion rate increases progressively with age and exceeds 15,000 ug/24 hr at 9 months of age (J:94602)
• kidney shows dilation of the ducts, atrophy of tubular cells, protein casts in the duct lumen, and prominent infiltration of mononuclear cells (J:94602)
• kidney shows dilation of the ducts, atrophy of tubular cells, protein casts in the duct lumen, and prominent infiltration of mononuclear cells (J:94602)
• glomeruli exhibit a thickened and irregular basement membrane (J:94602)
• glomeruli exhibit a thickened and irregular basement membrane (J:94602)
• expanded mesangium showing enlarged mesangial fraction and mesangial volume, with the greatest rate increase during 2.5-6 months of age (J:94602)
• expanded mesangium showing enlarged mesangial fraction and mesangial volume, with the greatest rate increase during 2.5-6 months of age (J:94602)
• diffuse and nodular expansion of mesangial matrix in mutants over 2 months of age (J:94602)
• diffuse and nodular expansion of mesangial matrix in mutants over 2 months of age (J:94602)
• diffuse and nodular glomerulosclerotic lesions (J:94602)
• nodules are acellular and are similar to Kimmelsteil-Wilson lesions in size (J:94602)
• diffuse and nodular glomerulosclerotic lesions (J:94602)
• nodules are acellular and are similar to Kimmelsteil-Wilson lesions in size (J:94602)
• glomerular volume is enlarged, with the greatest rate increase during 2.5-6 months of age (J:94602)
• glomerular volume is enlarged, with the greatest rate increase during 2.5-6 months of age (J:94602)
• seen in many mutants over 5 months of age (J:94602)
• seen in many mutants over 5 months of age (J:94602)
• 2-fold increase in kidney weight between 2 and 5 months of age (J:94602)
• 2-fold increase in kidney weight between 2 and 5 months of age (J:94602)
• expansion of kidney tubules; average cortical tubule cross-sectional area (minus the lumen) is 34% greater in 9 month old mutants than controls (J:94602)
• expansion of kidney tubules; average cortical tubule cross-sectional area (minus the lumen) is 34% greater in 9 month old mutants than controls (J:94602)
• significant fibrosis in the kidney by 5 months of age (J:94602)
• significant fibrosis in the kidney by 5 months of age (J:94602)
• tubulointerstitial fibrosis (J:94602)
• tubulointerstitial fibrosis (J:94602)
• many mutants over 5 months of age exhibit bladder stasis (J:94602)
• many mutants over 5 months of age exhibit bladder stasis (J:94602)
• distended bladders are seen in many mutants over 5 months of age (J:94602)
• distended bladders are seen in many mutants over 5 months of age (J:94602)
• glomerular filtration rate increases significantly from 2 to 3 months of age but then decreases significantly from 5 to 9 months of age (J:94602)
• decline in glomerular filtration rate coincides with an increase in renal vascular resistance (J:94602)
• glomerular filtration rate increases significantly from 2 to 3 months of age but then decreases significantly from 5 to 9 months of age (J:94602)
• decline in glomerular filtration rate coincides with an increase in renal vascular resistance (J:94602)
• by 2 months of age (J:94602)
• by 2 months of age (J:94602)

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:94602


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory