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Phenotypes Associated with This Genotype
Genotype
MGI:4359814
Allelic
Composition
Ttntm1Brge/Ttn+
Genetic
Background
B6.Cg-Ttntm1Brge
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ttntm1Brge mutation (0 available); any Ttn mutation (538 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• under normal condition, mice exhibit normal cardiac function and mechanical properties
• after 2 weeks of treatment with angiotensin II, mice exhibit increased left ventricular end-diastolic diameter (LVEDD) compared with similarly treated wild-type mice
• however, a normal decrease in LVEDD a week after angiotensin II treatment is observed
• mice treated with angiotensin II or isoproterenol exhibit increased left ventricular dilation compared with similarly treated wild-type mice
• following treatment with angiotensin II or isoproterenol
• following treatment with angiotensin II or isoproterenol
• after 1 and 2 weeks of treatment with angiotensin II, mice exhibit decreased fractional shortening compared with similarly treated wild-type mice
• after treatment with isoproterenol, mice exhibit reduced ejection fraction and fractional shortening compared with similarly treated wild-type mice

homeostasis/metabolism
• mice treated with angiotensin II or isoproterenol exhibit left ventricular dilation, decreased fractional shortening, increased left ventricular end-diastolic diameter, and increased cardiac interstitial fibrosis compared with similarly treated wild-type mice

muscle
• following treatment with angiotensin II or isoproterenol
• after 1 and 2 weeks of treatment with angiotensin II, mice exhibit decreased fractional shortening compared with similarly treated wild-type mice
• after treatment with isoproterenol, mice exhibit reduced ejection fraction and fractional shortening compared with similarly treated wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Cardiomyopathy, Dilated, 1G; CMD1G 604145 J:152736


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory