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Phenotypes Associated with This Genotype
Genotype
MGI:4359785
Allelic
Composition
Ccr6tm1.1Jmf/Ccr6tm1.1Jmf
Genetic
Background
B6.129-Ccr6tm1.1Jmf
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr6tm1.1Jmf mutation (0 available); any Ccr6 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Ccr6tm1.1Jmf/Ccr6tm1.1Jmf mice are resisant to IL23-induced acanthosis and dermal inflammation

immune system
• CD4+ T cells fail to migrate into intradermal sites where IL-23 has been injected unlike compared to wild-type controls that have a 2-fold increase
• CD11b+CD11c+ dendritic cells fail to migrate into intradermal sites where IL-23 has been injected compared to wild-type controls that have a 2-fold increase
• mice fail to increase IL-22 levels to the same extent as controls when administered IL-23 due to decreased trafficking of lymphocytes to injection site
• mice fail to develop a psoriasis-like inflammation when IL-23 is injected into the intradermal portion of the ear as do the wild-type controls

hematopoietic system
• CD4+ T cells fail to migrate into intradermal sites where IL-23 has been injected unlike compared to wild-type controls that have a 2-fold increase


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/16/2019
MGI 6.14
The Jackson Laboratory