Phenotypes Associated with This Genotype

Genotype
MGI:4359785

• Allelic Composition: Ccr6^tm1.1Jmf/Ccr6^tm1.1Jmf
• Genetic Background: B6.129-Ccr6^tm1.1Jmf

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Ccr6^tm1.1Jmf/Ccr6^tm1.1Jmf mice are resisant to IL23-induced acanthosis and dermal inflammation

immune system

abnormal CD4-positive, alpha-beta T cell physiology ( J:152716 )

• CD4⁺ T cells fail to migrate into intradermal sites where IL-23 has been injected unlike compared to wild-type controls that have a 2-fold increase

abnormal dendritic cell physiology ( J:152716 )

• CD11b⁺CD11c⁺ dendritic cells fail to migrate into intradermal sites where IL-23 has been injected compared to wild-type controls that have a 2-fold increase

abnormal interleukin secretion ( J:152716 )

• mice fail to increase IL-22 levels to the same extent as controls when administered IL-23 due to decreased trafficking of lymphocytes to injection site

decreased inflammatory response ( J:152716 )

• mice fail to develop a psoriasis-like inflammation when IL-23 is injected into the intradermal portion of the ear as do the wild-type controls

hematopoietic system

abnormal CD4-positive, alpha-beta T cell physiology ( J:152716 )

• CD4⁺ T cells fail to migrate into intradermal sites where IL-23 has been injected unlike compared to wild-type controls that have a 2-fold increase