Phenotypes Associated with This Genotype

Genotype
MGI:4359732

• Allelic Composition: Dp(7Herc2-Mkrn3)1Taku/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:151648 )

N • mice with a maternally (matDp/+) and paternally (patDp/+) inherited duplication bred normally and were fertile

N • nosignificant abnormality was detected in H&E-stained sections of the olfactory bulb, cerebral cortex, hippocampus, amygdala, corpus callosum, and cerebellum either macroscopically or at the microscopic level

N • no anatomical nor functional defects are found of the olfactory system in paternally inherited duplication bred mice

growth/size/body

increased susceptibility to age related obesity ( J:151648 )

• the patDp/+ male mice began to show an increase in body weight compared to wild-type (WT) mice after 15 weeks, and the body weight of patDp/+ was significantly greater than that of the WT after 20 weeks

cellular

genetic imprinting ( J:151648 )

• maternal and paternal allele-specific methylation is conserved in the mice with the duplicated allele

behavior/neurological

abnormal cued conditioning behavior ( J:151648 )

• patDp/+ mice showed higher freezing scores in the altered contextual environment than did the WT controls

increased anxiety-related response ( J:151648 )

• the patDp/+ mice show increased anxiety

increased fear-related response ( J:151648 )

• the patDp/+ mice show a generalized fear

increased startle reflex ( J:151648 )

• the patDp/+ mice show increased acoustic startle responce for 110-dB stimulus but not for 12-dB

enhanced coordination ( J:151648 )

• the patDp/+ mice show increased time for latency to fall on rotarod test

abnormal social/conspecific interaction behavior ( J:151648 )

• in mice with a paternally inherited duplication in a three-chamber social interaction test

• patDp/+ mice do not respond as flexibly as WT and matDp/+ mice to a change in situation

• no impariment in spatial learning in patDp/+ mice

decreased vocalization ( J:151648 )

• ultrasonic vocalizations (USVs) of neonatal mice that were separated from their dams are abnormal amoung patDp/+ mice

• the total number of vocalizations ranging from both audible and ultrasonic bands emitted by pairs of patDp/+ mice was significantly decreased compared with that of a WT pair

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:151648