About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4358598
Allelic
Composition		 Prf1tm1Sdz/Prf1tm1Sdz
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prf1tm1Sdz mutation (13 available); any Prf1 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired natural killer cell mediated cytotoxicity ( J:73948 )
• activated splenic NK cells are unable to kill 4T1 or Renca tumor target cells

hematopoietic system
impaired natural killer cell mediated cytotoxicity ( J:73948 )
• activated splenic NK cells are unable to kill 4T1 or Renca tumor target cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory