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Phenotypes Associated with This Genotype
Genotype
MGI:4357766
Allelic
Composition
Tg(Vav1-NUP98/HOXD13)C1Apla/0
Genetic
Background
FVB/N-Tg(Vav1-NUP98/HOXD13)C1Apla
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice do not survive past 14 months, displaying a spectrum of hematologic malignancies at time of death, with individual mice exhibiting various leukemias or myelodysplastic syndrome (MDS)

hematopoietic system
• peripheral blood cytopenia and dysplasia are observed in mutants
• observed in contrast to littermate controls at 4 to 7 months
• bone marrow shows increased apoptosis compared to control littermates at 5 months
• bone marrow (from tibia or femur) is hypercellular (total number of nucleated cells) in some mice at 5 months
• dysplastic megakaryocytes with hypolobulated nuclei and increased nuclear-cytoplasmic ratios are observed in bone marrow of mutants but not in controls at 5 months
• dysplastic multinucleated erythroblasts are observed bone marrow of mutants at 5 months but not in controls; some erythroblasts with clefted nuclei are observed
• numbers of erythroblasts in bone marrow is higher than in controls
• mutants show trend (not statistically significant) to increased mean cell volume
• circulating nucleated red blood cells are seen seen in peripheral blood smears from animals at 4 to 7 months
• seen in peripheral blood smears from animals at 4 to 7 months
• seen in peripheral blood smears from animals at 4 to 7 months
• seen in peripheral blood smears from animals at 4 to 7 months
• hypersegmented neutrophils are seen in peripheral blood smears from animals at 4 to 7 months
• giant platelets are seen in peripheral blood smears from animals at 4 to 7 months
• compared to littermate controls at 4 to 7 months

neoplasm
• at time of death (around or before 14 months), some animals develop megakaryocytic leukemia, erythroid leukemia, undifferentiated leukemia, myeloid leukemia with maturation, and precursor-T lymphoblastic lymphoma/leukemia (pre-T LBL) or pre-malignant myelodysplastic syndrome (MDS)

immune system
• hypersegmented neutrophils are seen in peripheral blood smears from animals at 4 to 7 months
• compared to littermate controls at 4 to 7 months

Mouse Models of Human Disease
OMIM ID Ref(s)
Myelodysplastic Syndrome; MDS 614286 J:107446


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory