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Phenotypes Associated with This Genotype
Genotype
MGI:4355230
Allelic
Composition
Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae
Tg(Thy1-APPSwDutIowa)BWevn/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm3(APOE*4)Mae mutation (3 available); any Apoe mutation (68 available)
Tg(Thy1-APPSwDutIowa)BWevn mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• increased number of neuroreactive microglia in cortex
• decreased number of neuroreactive microglia in thalamic region
• plaque deposition in cortical parenchyma increased 20%
• reduced deposition in cerebral microvasculature
• microglia are tightly associated with parenchymal plaque amyloid
• increased number of neuroreactive astrocytes in cortex
• decreased number of neuroreactive astrocytes in thalamic region

hematopoietic system
• increased number of neuroreactive microglia in cortex
• decreased number of neuroreactive microglia in thalamic region

immune system
• increased number of neuroreactive microglia in cortex
• decreased number of neuroreactive microglia in thalamic region

homeostasis/metabolism
• plaque deposition in cortical parenchyma increased 20%
• reduced deposition in cerebral microvasculature
• microglia are tightly associated with parenchymal plaque amyloid

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:136318


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory