Mouse Genome Informatics
cx
    Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae
Tg(Thy1-APPSwDutIowa)BWevn/?

involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
other phenotype
• plaque deposition in cortical parenchyma increased 20%
• reduced deposition in cerebral microvasculature
• microglia are tightly associated with parenchymal plaque amyloid

nervous system
• increased number of neuroreactive microglia in cortex
• decreased number of neuroreactive microglia in thalamic region
• increased number of neuroreactive astrocytes in cortex
• decreased number of neuroreactive astrocytes in thalamic region
• plaque deposition in cortical parenchyma increased 20%
• reduced deposition in cerebral microvasculature
• microglia are tightly associated with parenchymal plaque amyloid

hematopoietic system
• increased number of neuroreactive microglia in cortex
• decreased number of neuroreactive microglia in thalamic region

immune system
• increased number of neuroreactive microglia in cortex
• decreased number of neuroreactive microglia in thalamic region

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:136318