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Phenotypes Associated with This Genotype
Genotype
MGI:4355229
Allelic
Composition
Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae
Tg(APPSWE)2576Kha/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm3(APOE*4)Mae mutation (3 available); any Apoe mutation (71 available)
Tg(APPSWE)2576Kha mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• increased levels of Amyloid beta 1-40 in cortical extracts at 3 months of age
• increased ratio of Amyloid beta 40:42 in cortical extracts at 3 months of age
• decreased ratio of Amyloid beta 40:42 in cerebrospinal fluid at 3 months of age
• deposition delayed until after 12 months of age
• Amyloid beta deposition starts around 12-15 months of age
• deposition is almost exclusively in cerebral blood vessels with very few parenchymal plaques at 15 months
• Amyloid beta deposition starts around 12-15 months of age
• deposition is almost exclusively in cerebral blood vessels

homeostasis/metabolism
• increased levels of Amyloid beta 1-40 in cortical extracts at 3 months of age
• increased ratio of Amyloid beta 40:42 in cortical extracts at 3 months of age
• decreased ratio of Amyloid beta 40:42 in cerebrospinal fluid at 3 months of age
• deposition delayed until after 12 months of age
• Amyloid beta deposition starts around 12-15 months of age
• deposition is almost exclusively in cerebral blood vessels with very few parenchymal plaques at 15 months
• Amyloid beta deposition starts around 12-15 months of age
• deposition is almost exclusively in cerebral blood vessels

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:98636


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory