Mouse Genome Informatics
cx
    Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae
Tg(APPSWE)2576Kha/?

involves: 129P2/OlaHsd * C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
other phenotype
• Amyloid beta deposition starts around 12-15 months of age
• deposition is almost exclusively in cerebral blood vessels
• increased levels of Amyloid beta 1-40 in cortical extracts at 3 months of age
• increased ratio of Amyloid beta 40:42 in cortical extracts at 3 months of age
• decreased ratio of Amyloid beta 40:42 in cerebrospinal fluid at 3 months of age
• deposition delayed until after 12 months of age
• Amyloid beta deposition starts around 12-15 months of age
• deposition is almost exclusively in cerebral blood vessels with very few parenchymal plaques at 15 months

nervous system
• Amyloid beta deposition starts around 12-15 months of age
• deposition is almost exclusively in cerebral blood vessels
• increased levels of Amyloid beta 1-40 in cortical extracts at 3 months of age
• increased ratio of Amyloid beta 40:42 in cortical extracts at 3 months of age
• decreased ratio of Amyloid beta 40:42 in cerebrospinal fluid at 3 months of age
• deposition delayed until after 12 months of age
• Amyloid beta deposition starts around 12-15 months of age
• deposition is almost exclusively in cerebral blood vessels with very few parenchymal plaques at 15 months

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:98636