Phenotypes Associated with This Genotype

Genotype
MGI:4355162

• Allelic Composition: Klf2^tm2Ling/Klf2^tm2Ling; Tg(Cd4-cre)1Cwi/?
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal T cell differentiation ( J:151604 )

• single positive (SP) alpha-beta thymocytes express high levels of CXCR3

• CD8⁺ SP thymocytes express higher levels of CXCR3 than CD4⁺ SP thymocytes

• mixed bone marrow chimera experiments suggest CXCR3 expression is extrinsic to the thymocytes

• SP thymocytes secrete high levels of IL-4

• mixed bone marrow chimera experiments also demonstrate that a cell intrinsic defect in emigration of mutant single positive thymocytes from the thymus

decreased T cell number ( J:151604 )

• mice have severe T cell lymphopenia

increased single-positive T cell number ( J:151604 )

• single positive thymocytes are increased

increased IgE level ( J:151604 )

• IgE levels are increased 33-fold

increased IgG1 level ( J:151604 )

• IgG1 levels are modestly increased

immune system

abnormal T cell differentiation ( J:151604 )

• single positive (SP) alpha-beta thymocytes express high levels of CXCR3

• CD8⁺ SP thymocytes express higher levels of CXCR3 than CD4⁺ SP thymocytes

• mixed bone marrow chimera experiments suggest CXCR3 expression is extrinsic to the thymocytes

• SP thymocytes secrete high levels of IL-4

• mixed bone marrow chimera experiments also demonstrate that a cell intrinsic defect in emigration of mutant single positive thymocytes from the thymus

decreased T cell number ( J:151604 )

• mice have severe T cell lymphopenia

increased single-positive T cell number ( J:151604 )

• single positive thymocytes are increased

increased IgE level ( J:151604 )

• IgE levels are increased 33-fold

increased IgG1 level ( J:151604 )

• IgG1 levels are modestly increased

increased interleukin-4 secretion ( J:151604 )

• single-positive thymocytes produce about four-fold more IL-4 compared to controls