Phenotypes Associated with This Genotype

Genotype
MGI:4354646

• Allelic Composition: Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to experimental autoimmune encephalomyelitis ( J:115225 )

• following treatment with MOG

decreased susceptibility to bacterial infection ( J:50903 )

• mice exhibit reduced Pseudomonas aerugiosa exotoxin-induced liver failure compared with similarly treated wild-type mice

increased susceptibility to parasitic infection ( J:114203 )

• T. gondii-exposed mice exhibit increased bacterial load compared with similarly treated wild-type mice

• however, recruitment and intracerebral cell movement is normal in T. gondii-exposed mice