Analysis Tools
nervous system
|
• low threshold, rapid adapting mechanoreceptors exhibit reduced sensitivity compared with wild-type mechanoreceptors
• low threshold, rapid adapting mechanoreceptor stimulus response function exhibits reduced discharge frequency and flattens unlike in wild-type mechanoreceptors
• low threshold, rapid adapting mechanoreceptors exhibit reduced sensitivity between 5 and 20 um displacement unlike wild-type mechanoreceptor
• the stimulus-response of slowly adapting mechanoreceptor exhibits decreased sensitivity compared to wild-type mechanoreceptors
• however, sensory neurons exhibit normal response to current injection
|
hearing/vestibular/ear
|
• pH changes fail to generate firing of action potentials in spiral ganglion unlike similarly treated wild-type cells
• proton-induced current flows in spiral ganglion compared with wild-type cells
• following exposure to 110 dB white-band noise, mice exhibit a decrease in their susceptibilities to noise-induced temporary threshold shifts compared with wild-type mice
• however, auditory brainstem response is normal
|
cardiovascular system
|
• mice exhibit decreased pressure-induced constriction of the middle cerebral artery in the presence of calcium unlike similarly treated wild-type mice
• mice develop myogenic tone with increases in intraluminal pressure but generate less tone at every pressure step compared with similarly treated wild-type mice
|
behavior/neurological
| N |
• hyperalgesia induced by repeated acid injections is normal
|
taste/olfaction
| N |
• mice exhibit normal physiological responses to acid taste stimuli
|
muscle
|
• mice exhibit decreased pressure-induced constriction of the middle cerebral artery in the presence of calcium unlike similarly treated wild-type mice
• mice develop myogenic tone with increases in intraluminal pressure but generate less tone at every pressure step compared with similarly treated wild-type mice
|
