Phenotypes Associated with This Genotype

Genotype
MGI:4354335

• Allelic Composition: Gap43^tm1Kmr/Gap43^tm1Kmr
• Genetic Background: 129/Sv-Gap43^tm1Kmr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:56646 )

• less than 5% of mice born survive weaning

postnatal lethality, complete penetrance ( J:56646 )

• 50% of mice die within 2 days of birth and most of the remainder die between P14 and P21

nervous system

abnormal axon extension ( J:56646 )

• branching of thalamocortical afferents is inappropriate compared to in wild-type mice producing larger than barrel branches

abnormal axon guidance ( J:56646 )

• pathfinding of thalamocortical neurons is abnormal

• thalamococortical afferents are misrouted due to imprecise targeting in the cortex unlike in wild-type mice

abnormal cerebral cortex morphology ( J:56646 )

• thalamocortical afferents are disrupted compared to in wild-type mice

• pathfinding of thalamocortical neurons is abnormal

disorganized barrel cortex ( J:56646 )

• the presumptive barrel field contains irregularly shaped blotches when labeled for the serotonin transporter unlike in wild-type mice

• by P90, standard Nissl staining fails to reveal a normal barrel pattern

cellular

abnormal axon extension ( J:56646 )

• branching of thalamocortical afferents is inappropriate compared to in wild-type mice producing larger than barrel branches

abnormal axon guidance ( J:56646 )

• pathfinding of thalamocortical neurons is abnormal

• thalamococortical afferents are misrouted due to imprecise targeting in the cortex unlike in wild-type mice