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Phenotypes Associated with This Genotype
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phenotype observed in females
phenotype observed in males
N normal phenotype
• by 9 months, mice develop atrophic fibers with basophilic appearance
• at 18 months, mice exhibit atrophic fibers and fibers with internal nuclei, basophilic inclusions, and vacuoles
• at 9 months, mice exhibit scattered muscle fibers with granular blue basophilic appearance indicating degeneration unlike in wild-type mice
• at 7 to 9 months and worse at 12 to 14 months

• beginning at 3 months, mice exhibit amyloid depositions around the endomysial capillaries and the surrounding muscle fibers unlike in wild-type mice
• amyloidosis progresses with age
• by 18 months, extensive amyloidosis in the endomysium with occasional punctate deposits within some muscle fibers
• between 9 and 18 months, mice exhibit fibrillar deposits between the sarcolemma and the endomysium unlike in wild-type mice
• at 18 months, intranuclear inclusions are observed in muscle cells

Mouse Models of Human Disease
OMIM ID Ref(s)
Amyloidosis, Finnish Type 105120 J:150825

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.07
The Jackson Laboratory