Mouse Genome Informatics
hm
    Nlgn3tm1Bros/Nlgn3tm1Bros
B6.Cg-Nlgn3tm1Bros
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
N
• mice exhibit normal sucrose preference and hippocampal memory function in a Morris water maze (J:151116)
• mice display decreased freezing in hippocampus-dependent contextual fear conditioning compared with wild-type mice (J:151116)
• mice display decreased freezing in hippocampus-independent cued fear conditioning compared with wild-type mice (J:151116)
• mice exhibit increased motor activity, total distance traveled, and mean velocity compared with wild-type mice (J:151116)
• in an elevated plus maze, mice exhibit an increase in total distance traveled compared with wild-type mice (J:151116)
• in a hole board test, mice exhibit increased exploration compared with wild-type mice (J:151116)
• mice exhibit no preference for new stranger mouse unlike wild-type mice (J:151116)
• mice exhibit reduced ultrasound vocalization compared with wild-type mice (J:151116)

nervous system
N
• mice exhibit normal prepulse inhibition and seizure propensity (J:151116)
• brain volume is decreased compared to in wild-type mice (J:151116)

taste/olfaction
• mice exhibit increased latency to finding buried food compared with wild-type mice (J:151116)

Mouse Models of Human Disease
OMIM IDRef(s)
Autism, Susceptibility to, X-Linked 1; AUTSX1 300425 J:151116