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Phenotypes Associated with This Genotype
Genotype
MGI:4353654
Allelic
Composition
Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic
Background
B6.Cg-Nlgn3tm1Bros
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3tm1Bros mutation (0 available); any Nlgn3 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice exhibit normal sucrose preference and hippocampal memory function in a Morris water maze
• mice display decreased freezing in hippocampus-dependent contextual fear conditioning compared with wild-type mice
• mice display decreased freezing in hippocampus-independent cued fear conditioning compared with wild-type mice
• mice exhibit increased motor activity, total distance traveled, and mean velocity compared with wild-type mice
• in an elevated plus maze, mice exhibit an increase in total distance traveled compared with wild-type mice
• in a hole board test, mice exhibit increased exploration compared with wild-type mice
• mice exhibit no preference for new stranger mouse unlike wild-type mice
• mice exhibit reduced ultrasound vocalization compared with wild-type mice

nervous system
N
• mice exhibit normal prepulse inhibition and seizure propensity
• brain volume is decreased compared to in wild-type mice

taste/olfaction
• mice exhibit increased latency to finding buried food compared with wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Autism, Susceptibility to, X-Linked 1; AUTSX1 300425 J:151116


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory