Phenotypes Associated with This Genotype

Genotype
MGI:4353654

• Allelic Composition: Nlgn3^tm1Bros/Nlgn3^tm1Bros
• Genetic Background: B6.Cg-Nlgn3^tm1Bros

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:151116 )

♀N • mice exhibit normal sucrose preference and hippocampal memory function in a Morris water maze

impaired contextual conditioning behavior ( J:151116 )

♀ • mice display decreased freezing in hippocampus-dependent contextual fear conditioning compared with wild-type mice

impaired cued conditioning behavior ( J:151116 )

♀ • mice display decreased freezing in hippocampus-independent cued fear conditioning compared with wild-type mice

increased exploration in new environment ( J:151116 )

♀ • in a hole board test, mice exhibit increased exploration compared with wild-type mice

increased locomotor activity ( J:151116 )

• mice exhibit increased motor activity, total distance traveled, and mean velocity compared with wild-type mice

• in an elevated plus maze, mice exhibit an increase in total distance traveled compared with wild-type mice

abnormal social investigation ( J:151116 )

♀ • mice exhibit no preference for new stranger mouse unlike wild-type mice

decreased vocalization ( J:151116 )

♀ • mice exhibit reduced ultrasound vocalization compared with wild-type mice

nervous system

nervous system phenotype ( J:151116 )

♀N • mice exhibit normal prepulse inhibition and seizure propensity

decreased brain size ( J:151116 )

♀ • brain volume is decreased compared to in wild-type mice

taste/olfaction

impaired olfaction ( J:151116 )

♀ • mice exhibit increased latency to finding buried food compared with wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:151116