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Phenotypes Associated with This Genotype
Genotype
MGI:4353391
Allelic
Composition		 B2mtm1Jae/B2mtm1Jae
Themistm1Lov/Themistm1Lov
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Jae mutation (8 available); any B2m mutation (122 available)
Themistm1Lov mutation (0 available); any Themis mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal CD8-positive, alpha-beta T cell differentiation ( J:151075 )
• CD3hi CD8 single-positive thymocytes are present in these mice
• these thymocytes are TCRhiCD69+ which indicates that they received positively selecting signals by interaction with self peptide-MHC class II complexes but are subsequently 'redirected' to the CD8 lineage

hematopoietic system
abnormal CD8-positive, alpha-beta T cell differentiation ( J:151075 )
• CD3hi CD8 single-positive thymocytes are present in these mice
• these thymocytes are TCRhiCD69+ which indicates that they received positively selecting signals by interaction with self peptide-MHC class II complexes but are subsequently 'redirected' to the CD8 lineage

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory