Phenotypes Associated with This Genotype

Genotype
MGI:4353387

• Allelic Composition: Themis^tm1Lov/Themis^tm1Lov
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell differentiation ( J:151075 )

• the ratio of mature (CD24^lo) to immature (CD24^hi) TCR^hiCD4+ thymocytes is much lower than in controls indicating a defect in differentiation

abnormal negative T cell selection ( J:151075 )

• the number of transitional CD4+CD8^int thymocytes is lower indicating a defect in positive selection

decreased CD4-positive, alpha-beta T cell number ( J:151075 )

• peripheral CD4 T cells numbers are reduced by about 75%

decreased CD8-positive, alpha-beta T cell number ( J:151075 )

• peripheral CD8 T cell numbers are reduced by about a third

increased memory T cell number ( J:151075 )

• relative percentage of memory T cells is increased likely reflecting lymphopenia-driven population expansion

decreased regulatory T cell number ( J:151075 )

• CD4 regulatory T cell numbers are reduced in these mice

• the deletion of Vbeta8+ CD4SP thymocytes but not Vbeta8+ CD8SP thymocytes induced by the 'superantigen' staphylococcus enterotoxin B is impaired in these mice

decreased single-positive T cell number ( J:151075 )

• CD4 and CD8 single-positive thymocytes are reduced by a third to a half compared to controls

hematopoietic system

abnormal T cell differentiation ( J:151075 )

• the ratio of mature (CD24^lo) to immature (CD24^hi) TCR^hiCD4+ thymocytes is much lower than in controls indicating a defect in differentiation

abnormal negative T cell selection ( J:151075 )

• the number of transitional CD4+CD8^int thymocytes is lower indicating a defect in positive selection

decreased CD4-positive, alpha-beta T cell number ( J:151075 )

• peripheral CD4 T cells numbers are reduced by about 75%

decreased CD8-positive, alpha-beta T cell number ( J:151075 )

• peripheral CD8 T cell numbers are reduced by about a third

increased memory T cell number ( J:151075 )

• relative percentage of memory T cells is increased likely reflecting lymphopenia-driven population expansion

decreased regulatory T cell number ( J:151075 )

• CD4 regulatory T cell numbers are reduced in these mice

• the deletion of Vbeta8+ CD4SP thymocytes but not Vbeta8+ CD8SP thymocytes induced by the 'superantigen' staphylococcus enterotoxin B is impaired in these mice

decreased single-positive T cell number ( J:151075 )

• CD4 and CD8 single-positive thymocytes are reduced by a third to a half compared to controls