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Phenotypes Associated with This Genotype
Genotype
MGI:4353115
Allelic
Composition
Tg(TcrAND)53Hed/?
Themistm1Gasc/Themistm1Gasc
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TcrAND)53Hed mutation (2 available)
Themistm1Gasc mutation (1 available); any Themis mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• positive selection is almost completely blocked in these mice
• the proportion and number of double-positive thymocytes is greater than controls
• very few single-positive thymocytes are generated in the thymus
• peripheral CD4 T cell numbers are severely reduced
• very few single-positive thymocytes are generated in the thymus

hematopoietic system
• positive selection is almost completely blocked in these mice
• the proportion and number of double-positive thymocytes is greater than controls
• very few single-positive thymocytes are generated in the thymus
• peripheral CD4 T cell numbers are severely reduced
• very few single-positive thymocytes are generated in the thymus


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory