About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4353113
Allelic
Composition
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Themistm1Gasc/Themistm1Gasc
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)
Themistm1Gasc mutation (1 available); any Themis mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the negative selection that normally occurs to transgenic thymocytes in male mice is incomplete in these mice with some single-positive thymocytes present in the thymus
• the positive selection that normally occurs to transgeneic thymocytes in female mice is incomplete in these mice with few CD8 T cells being generated

hematopoietic system
• the negative selection that normally occurs to transgenic thymocytes in male mice is incomplete in these mice with some single-positive thymocytes present in the thymus
• the positive selection that normally occurs to transgeneic thymocytes in female mice is incomplete in these mice with few CD8 T cells being generated


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory