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Phenotypes Associated with This Genotype
Genotype
MGI:4352950
Allelic
Composition		 Antxr1tm1.2Lepp/Antxr1tm1.2Lepp
Antxr2tm1.2Lepp/Antxr2tm1.2Lepp
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Antxr1tm1.2Lepp mutation (1 available); any Antxr1 mutation (29 available)
Antxr2tm1.2Lepp mutation (0 available); any Antxr2 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to induced morbidity/mortality ( J:150952 )
• mice are completely resistant to up to 5 doses (100 ug each) of anthrax lethal toxin

cellular
decreased sensitivity to induced cell death ( J:150952 )
• MEFs are completely resistant to anthrax toxin protective antigen plus FP59 induced cell death unlike wild-type cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory