Analysis Tools
mortality/aging
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• unlike in wild-type mice, infection with T. gondii leads to death within 3 to 5 weeks
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immune system
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• mice exhibit fewer metallophillic macrophages and ER-TR9+ marginal zone macrophages compared with wild-type mice
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• the ratios of B to T cells in the spleen, blood, and lymph nodes are decreased compared to in wild-type mice
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• unchallenged mice exhibit smaller B cell compartments compared to in wild-type mice
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• impaired following infection with influenza virus
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• mice challenged with influenze or T. gondii exhbit a progressive loss of B cells from secondary lymphoid organs unlike in similarly treated wild-type mice
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• mice exhibit fewer metallophillic macrophages that are no longer organized in a continuous ring of cells as in wild-type mice
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• no ER-TR9+ marginal zone macrophages are detected unlike in wild-type mice
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• red pulp contains infiltrates from the white pulp unlike in wild-type mice
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• in unchallenged mice and mice challenged with influenze virus or T. gondii fail to exhibit splenic germinal centers unlike similarly treated wild-type mice
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• in mice challenged with TNP-KLH fewer PNA+ germinal centers are formed compared to in similarly treated wild-type mice
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• spleen B cell follicles lack distinct organization unlike in wild-type mice
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• following infection with influenza virus
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• nitric oxide production of T cells in response to STAg is reduced compared to in similarly treated wild-type cells
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• lymph node B cell follicles lack distinct organization unlike in wild-type mice
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• variable
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• soluble tachyzoite antigen (STAg)-treated splenocyted exhibit a rapid decline in IFN-gamma production compared with similarly treated wild-type cells
• T cell production of IFN-gamma following exposure to STAg is impaired while that of NK cells is normal
• however, T cell IFN-gamma production in response to anti-CD3 treatment is normal
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• in STAg-treated T cells
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• unlike in wild-type mice, infection with T. gondii leads to inflammation in mulitpe tissues, thymus necrosis, secondary lymphoid tissue acellularity, loss of T cells from secondary lymphoid organs, and death within 3 to 5 weeks
• soluble tachyzoite antigen (STAg)-treated splenocyted exhibit a rapid decline in IFN-gamma production compared with similarly treated wild-type cells
• T cell production of IFN-gamma following exposure to STAg is impaired while that of NK cells is normal
• nitric oxide and IL12 production of T cells in response to STAg is reduced compared to in similarly treated wild-type cells
• cytotoxic T lymphocyte activity towards T. gondii is impaired compared to in similarly treated wild-type mice
• mice fail to mount a protective T helper 1 immune resposne against T. gondii infection unlike similarly treated wild-type mice
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homeostasis/metabolism
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• nitric oxide production of T cells in response to STAg is reduced compared to in similarly treated wild-type cells
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hematopoietic system
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• mice exhibit fewer metallophillic macrophages and ER-TR9+ marginal zone macrophages compared with wild-type mice
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• the ratios of B to T cells in the spleen, blood, and lymph nodes are decreased compared to in wild-type mice
|
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• unchallenged mice exhibit smaller B cell compartments compared to in wild-type mice
|
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• impaired following infection with influenza virus
|
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• mice challenged with influenze or T. gondii exhbit a progressive loss of B cells from secondary lymphoid organs unlike in similarly treated wild-type mice
|
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• mice exhibit fewer metallophillic macrophages that are no longer organized in a continuous ring of cells as in wild-type mice
|
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• no ER-TR9+ marginal zone macrophages are detected unlike in wild-type mice
|
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• red pulp contains infiltrates from the white pulp unlike in wild-type mice
|
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• in unchallenged mice and mice challenged with influenze virus or T. gondii fail to exhibit splenic germinal centers unlike similarly treated wild-type mice
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• in mice challenged with TNP-KLH fewer PNA+ germinal centers are formed compared to in similarly treated wild-type mice
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• spleen B cell follicles lack distinct organization unlike in wild-type mice
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• following infection with influenza virus
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• nitric oxide production of T cells in response to STAg is reduced compared to in similarly treated wild-type cells
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