Phenotypes Associated with This Genotype

Genotype
MGI:3852640

• Allelic Composition: Tnfrsf11b^tm1Eac/Tnfrsf11b^tm1Eac
• Genetic Background: involves: 129S4/SvJaeSor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal mandible morphology ( J:67105 )

• thickened mandibular corpus

abnormal long bone morphology ( J:67105 )

• fractured diaphyses of long bones often seen in older mice

short femur neck ( J:67105 )

• shortened femoral neck in 2 month old mice

increased diameter of long bones ( J:67105 )

• increased outer diameter of long bones

abnormal bone structure ( J:67105 )

decreased bone mineral density ( J:67105 )

• dramatically reduced bone density in 3 month old males

abnormal compact bone morphology ( J:67105 )

• cortical bone is more porous

immune system

abnormal immune system morphology ( J:67105 )

abnormal pro-B cell differentiation ( J:67105 )

• defective pro-B cell to pre-B cell transition

increased pro-B cell number ( J:67105 )

• increased proliferative response to IL-7 (1.7-2 fold increase)

increased B cell number ( J:67105 )

• increased number of peripheral B cells

increased immature B cell number ( J:67105 )

• 53% more IgM (high) IgD (low) B cells

abnormal immune system physiology ( J:67105 )

abnormal immunoglobulin level ( J:67105 )

• variable ability to mount an antibody response

• antibody response is comparable to controls overall

abnormal dendritic cell antigen presentation ( J:67105 )

• enhanced ability to stimulate T-cell proliferation

limbs/digits/tail

short femur neck ( J:67105 )

• shortened femoral neck in 2 month old mice

craniofacial

abnormal mandible morphology ( J:67105 )

• thickened mandibular corpus

hematopoietic system

abnormal pro-B cell differentiation ( J:67105 )

• defective pro-B cell to pre-B cell transition

increased pro-B cell number ( J:67105 )

• increased proliferative response to IL-7 (1.7-2 fold increase)

increased B cell number ( J:67105 )

• increased number of peripheral B cells

increased immature B cell number ( J:67105 )

• 53% more IgM (high) IgD (low) B cells

abnormal immunoglobulin level ( J:67105 )

• variable ability to mount an antibody response

• antibody response is comparable to controls overall