Phenotypes Associated with This Genotype

Genotype
MGI:3852410

• Allelic Composition: Mrgprd^tm1Mjz/Mrgprd^tm1Mjz
• Genetic Background: B6.129S1-Mrgprd^tm1Mjz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

hyporesponsive to tactile stimuli ( J:150802 )

• following exposure to mechanical stimuli, mice exhibit decreased mean firing rates compared with wild-type mice

• however, mechanical threshold and peak instantaneous frequency are normal

increased thermal nociceptive threshold ( J:150802 )

• mice exhibit decreased cold and heat sensitivity compared with wild-type mice

• mice exhibit a lower cold threshold and a higher heat threshold compared with wild-type mice

• peak instant frequency is decreased under heat conditions compared to in wild-type mice

• in mice subjected to a heat ramp, average firing rate of neurons is decreased compared to in wild-type mice

nervous system

abnormal single cell response ( J:150802 )

• in mice subjected to a heat ramp, average firing rate of neurons is decreased compared to in wild-type mice

• patch clamp studies reveal a higher rheobase than in wild-type neurons

• beta-alanine has no effect on firing rate unlike in wild-type neurons