Phenotypes Associated with This Genotype

Genotype
MGI:3851985

• Allelic Composition: Tg(BCL2)36Wehi/?
• Genetic Background: B6.Cg-Tg(BCL2)36Wehi/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased B cell apoptosis ( J:90963 )

• IL-21 fails to induce apoptosis in LPS-activated B cells as it does in wild-type mice

abnormal B cell proliferation ( J:90963 )

• anti-CD40 B cell proliferation is increased 3- to 5- fold in the presence of IL-21, which does not occur in wild-type controls

immune system

decreased B cell apoptosis ( J:90963 )

• IL-21 fails to induce apoptosis in LPS-activated B cells as it does in wild-type mice

abnormal B cell proliferation ( J:90963 )

• anti-CD40 B cell proliferation is increased 3- to 5- fold in the presence of IL-21, which does not occur in wild-type controls

cellular

decreased B cell apoptosis ( J:90963 )

• IL-21 fails to induce apoptosis in LPS-activated B cells as it does in wild-type mice

abnormal B cell proliferation ( J:90963 )

• anti-CD40 B cell proliferation is increased 3- to 5- fold in the presence of IL-21, which does not occur in wild-type controls