Mouse Genome Informatics
cn
    Gt(ROSA)26Sortm2(SNCA*119)Djmo/Gt(ROSA)26Sortm2(SNCA*119)Djmo
Tg(Th-cre)1Tmd/0

involves: 129 * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• 32% reduction in levels of striatal dopamine observed in 10-11 month old mice

homeostasis/metabolism
• increased levels of norepinephrine observed in striatum in 10-11 month old mice
• 32% reduction in levels of striatal dopamine observed in 10-11 month old mice
• increased levels of 5-HT observed in prefrontal cortex in 10-11 month old mice

Mouse Models of Human Disease
OMIM IDRef(s)
Parkinson Disease 1, Autosomal Dominant; PARK1 168601 J:150777