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Phenotypes Associated with This Genotype
Genotype
MGI:3851906
Allelic
Composition
Gt(ROSA)26Sortm2(SNCA*119)Djmo/Gt(ROSA)26Sortm2(SNCA*119)Djmo
Tg(Th-cre)1Tmd/0
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(SNCA*119)Djmo mutation (1 available); any Gt(ROSA)26Sor mutation (313 available)
Tg(Th-cre)1Tmd mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• 32% reduction in levels of striatal dopamine observed in 10-11 month old mice

homeostasis/metabolism
• increased levels of norepinephrine observed in striatum in 10-11 month old mice
• 32% reduction in levels of striatal dopamine observed in 10-11 month old mice
• increased levels of 5-HT observed in prefrontal cortex in 10-11 month old mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Parkinson Disease 1, Autosomal Dominant; PARK1 168601 J:150777


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory