Phenotypes Associated with This Genotype

Genotype
MGI:3851732

• Allelic Composition: Ehmt2^tm1Yshk/Ehmt2^tm1Yshk
• Genetic Background: B6.Cg-Ehmt2^tm1Yshk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:77998 )

• embryos die around E9.5-E12.5

embryo

embryonic growth arrest ( J:77998 )

• developmental arrest around E8; E9.5 embryos develop only to the 5-6 somite stage instead of to the wild-type 21-25 somite stage

cellular

abnormal cell physiology ( J:77998 )

• primary embryonic fibroblasts from E9 embryos show severe growth defects

abnormal apoptosis ( J:77998 )

• increase in apoptosis in E9.5 embryos