About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3851599
Allelic
Composition
Cngb1tm1Sjpi/Cngb1tm1Sjpi
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cngb1tm1Sjpi mutation (0 available); any Cngb1 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• at P35 rod appear swollen and nonuniform in shape with expanded and constricted regions consistent with the elongated disks (J:150504)
• at P35 rod appear swollen and nonuniform in shape with expanded and constricted regions consistent with the elongated disks (J:150504)
• at P18 - P24 outer segments are shorter, often bent and less rigid compared to wild-type controls (J:150504)
• at P20 outer segments appear misaligned and abnormal elongation of the disks is seen (J:150504)
• at P60 outer segments contain elongated membranous material that most likely originates from the disks (J:150504)
• by 3 - 4 months of age rod outer segments are lost due to progressive degeneration (J:150504)
• at P18 - P24 outer segments are shorter, often bent and less rigid compared to wild-type controls (J:150504)
• at P20 outer segments appear misaligned and abnormal elongation of the disks is seen (J:150504)
• at P60 outer segments contain elongated membranous material that most likely originates from the disks (J:150504)
• by 3 - 4 months of age rod outer segments are lost due to progressive degeneration (J:150504)
• complete loss of the photoreceptor layer by 1 year of age (J:150504)
• complete loss of the photoreceptor layer by 1 year of age (J:150504)
• rods have smaller circulating currents and are less sensitive to light stimulation compared to wild-type controls (J:150504)
• rods have smaller circulating currents and are less sensitive to light stimulation compared to wild-type controls (J:150504)

growth/size/body
N
• unlike mice homozygous for Cngb1tm1.1Biel, body weight is similar to controls (J:150504)
• unlike mice homozygous for Cngb1tm1.1Biel, body weight is similar to controls (J:150504)

nervous system
• at P35 rod appear swollen and nonuniform in shape with expanded and constricted regions consistent with the elongated disks (J:150504)
• at P35 rod appear swollen and nonuniform in shape with expanded and constricted regions consistent with the elongated disks (J:150504)
• at P18 - P24 outer segments are shorter, often bent and less rigid compared to wild-type controls (J:150504)
• at P20 outer segments appear misaligned and abnormal elongation of the disks is seen (J:150504)
• at P60 outer segments contain elongated membranous material that most likely originates from the disks (J:150504)
• by 3 - 4 months of age rod outer segments are lost due to progressive degeneration (J:150504)
• at P18 - P24 outer segments are shorter, often bent and less rigid compared to wild-type controls (J:150504)
• at P20 outer segments appear misaligned and abnormal elongation of the disks is seen (J:150504)
• at P60 outer segments contain elongated membranous material that most likely originates from the disks (J:150504)
• by 3 - 4 months of age rod outer segments are lost due to progressive degeneration (J:150504)
• complete loss of the photoreceptor layer by 1 year of age (J:150504)
• complete loss of the photoreceptor layer by 1 year of age (J:150504)

Mouse Models of Human Disease
OMIM ID Ref(s)
Retinitis Pigmentosa; RP 268000 J:150504


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory