Phenotypes Associated with This Genotype

Genotype
MGI:3851510

• Allelic Composition: Cnga2^tm1Gvr/Y
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:74854 )

♂ • mice exhibit a high level of neonatal lethality

♂ • however, litter size reduction within the first 24 hours after birth reduces neonatal lethality

nervous system

reduced long-term potentiation ( J:74854 )

♂ • long term potentiation induced by theta-burst stimulation is attenuated compared to in wild-type mice

♂ • however, long term potentiation induced by high-frequency stimulation is normal

decreased post-tetanic potentiation ( J:74854 )

♂ • after theta burst stimulation, the field excitatory postsynaptic potential slope at the first pulse of the third theta-burst set is less than in wild-type mice