Phenotypes Associated with This Genotype

Genotype
MGI:3851499

• Allelic Composition: Efnb3^tm1Henk/Efnb3^tm1Henk
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal axon pruning ( J:150550 )

• mossy fiber pruning is defective

• dentate granule cells cocultured with Cos-1 cells exhibit longer neurites than similarly treated wild-type cells due to defective pruning

• however, transfection with fusion of EB3-Grb4-SH3 restores neurite pruning activity in culture

abnormal axon morphology ( J:150550 )

• infra-pyramidal bundle (IPB) axons extend further into the CA3 area underneath the pyramidal neurons than in wild-type mice

• IPB length does not decrease with age unlike in wild-type mice

cellular

abnormal axon pruning ( J:150550 )

• mossy fiber pruning is defective

• dentate granule cells cocultured with Cos-1 cells exhibit longer neurites than similarly treated wild-type cells due to defective pruning

• however, transfection with fusion of EB3-Grb4-SH3 restores neurite pruning activity in culture