Phenotypes Associated with This Genotype

Genotype
MGI:3851497

• Allelic Composition: Shh^tm1.1Rseg/Shh^tm1.1Rseg
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

embryo phenotype ( J:150524 )

N • while organ size is reduced to various degrees, all organs are present and correctly localized unlike in Shh-null mice

growth/size/body

decreased body weight ( J:150524 )

• body weight of mice is 11% less than controls

nervous system

abnormal cerebellum external granule cell layer morphology ( J:150524 )

• granule cell precursor proliferation in the external granule cell layer is 30% less than controls at 3 days of age

• apoptosis is also decreased

decreased brain weight ( J:150524 )

• brain weight is 13% less than controls

small olfactory bulb ( J:150524 )

• olfactory bulb is 30% smaller by weight than controls

cerebellum hypoplasia ( J:150524 )

• cerebella is 31% smaller by weight than controls, which is disproportionately smaller to other organs

abnormal postnatal subventricular zone morphology ( J:150524 )

• proliferation of neural stem/precursors in the adult SVZ is decreased compared to controls

abnormal embryonic/fetal subventricular zone morphology ( J:150524 )

• proliferation of neural stem/precursors in E10.5 SVZ is decreased compared to controls

vision/eye

microphthalmia ( J:150524 )

• eyes are small but are well-spaced unlike Shh-null mice that have improperly spaced eyes