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Phenotypes Associated with This Genotype
Genotype
MGI:3851408
Allelic
Composition		 Gata4tm1Sho/Gata4tm1.1Wtp
Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1.1Wtp mutation (0 available); any Gata4 mutation (36 available)
Gata4tm1Sho mutation (0 available); any Gata4 mutation (36 available)
Nkx2-5tm1(cre)Rjs mutation (1 available); any Nkx2-5 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Edema, peripheral hemorrhage, and reduced coronary plexus in Gata4tm1.1Wtp/Gata4tm1Sho Nkx2-5tm1(cre)Rjs/Nkx2-5+ embryos and enlarged dilated ventricles and increased fibrosis in Gata4tm1.1Wtp/Gata4tm1Sho Tg(Myh6-cre)2182Mds/0 hearts

cardiovascular system
thin myocardium compact layer ( J:150452 )
• compact myocardium is thin
abnormal atrioventricular cushion morphology ( J:150452 )
• atrio-ventricular cushion defect is observed
abnormal coronary vessel morphology ( J:150452 )
• coronary vascular development is impaired
ventricular septal defect ( J:150452 )
• ventricular septal defect is observed
hemorrhage ( J:150452 )
• peripheral hemorrhage is observed at E13.5

homeostasis/metabolism
skin edema ( J:150452 )
• observed at E13.5

integument
skin edema ( J:150452 )
• observed at E13.5

muscle
thin myocardium compact layer ( J:150452 )
• compact myocardium is thin

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory