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Phenotypes Associated with This Genotype
Genotype
MGI:3851396
Allelic
Composition
Cbstm1Unc/Cbstm1Unc
Tg(Mt1-CBS*I278T)1Waku/0
Genetic
Background
involves: 129P2/OlaHsd * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbstm1Unc mutation (3 available); any Cbs mutation (40 available)
Tg(Mt1-CBS*I278T)1Waku mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• liver N-homocysteine levels in zinc-induced mice are 11.5-fold higher than in Cbstm1Unc Tg(Mt1-CBS* I278T)1Waku heterozygotes or Tg(Mt1-CBS* I278T)1Waku mice
• total liver homocysteine levels in zinc-induced mice are 51- to 75-fold higher than in Cbstm1Unc Tg(Mt1-CBS* I278T)1Waku heterozygotes or Tg(Mt1-CBS* I278T)1Waku mice
• N-homocysteine levels in zinc-induced mice are 3.3-fold greater than in Cbstm1Unc/Cbstm1Unc Tg(Mt1-CBS)25Waku mice
• plasma N-homocysteine levels in zinc-induced mice are 6.3-fold to 10.6-fold higher than in Cbstm1Unc Tg(Mt1-CBS* I278T)1Waku heterozygotes or Tg(Mt1-CBS* I278T)1Waku mice
• total plasma homocysteine levels in zinc-induced mice are 54- to 143-fold higher than in Cbstm1Unc Tg(Mt1-CBS* I278T)1Waku heterozygotes or Tg(Mt1-CBS* I278T)1Waku mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory