About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3851394
Allelic
Composition		 Batftm1.1Kmm/Batftm1.1Kmm
Genetic
Background		 129S6/SvEvTac-Batftm1.1Kmm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Batftm1.1Kmm mutation (3 available); any Batf mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal CD4-positive T cell differentiation ( J:150643 )
• culturing CD4+ T cells under Th17-polarizing conditions produces very few Th17 T cells
decreased interleukin-17 secretion ( J:150643 )
• CD8+ T cells and lamina propia T cells fail to produce IL-17
decreased interleukin-21 secretion ( J:150643 )
• CD4+ T cells cultured under Th17-polarizing conditions fail to produce IL-21
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:150643 )
• mice are completely resistant to EAE induced by MOG-peptide immunization
• T cells infiltrating the spinal cord of mice do not produce IL-17 after EAE induction in the manner that wild-type mice do

hematopoietic system
abnormal CD4-positive T cell differentiation ( J:150643 )
• culturing CD4+ T cells under Th17-polarizing conditions produces very few Th17 T cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory