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Phenotypes Associated with This Genotype
Genotype
MGI:3851194
Allelic
Composition
Rasgrf1tm1Kln/Rasgrf1tm1Kln
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrf1tm1Kln mutation (1 available); any Rasgrf1 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• hippocampal-dependent behavior is normal in spatial learning, Morris water maze, and radial-maze tests
• mice fail to exhibit as much success learning to avoid the electric shock compared with wild-type mice
• in a one-trial inhibitory avoidance, mice forget to avoid the dark chamber after 24 hours unlike wild-type mice
• in fear conditioning tests, mice exhibit diminished long-term memory compared with wild-type mice
• however, short-term memory is normal

nervous system
N
• brain morphology is normal
• long-lasting plasticity is absent
• larger than in wild-type mice in the amygdala and CA1 hippocampus
• following delivery of 3 trains of stimulation of 10-burst theta frequency, mice fail to exhibit enhancement of LTP unlike wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory